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BPR1M97

Chemical Structure : BPR1M97

CAS No.: 2059904-66-2

BPR1M97 (Dual MOP/NOP agonist)

Catalog No.: PC-38589Not For Human Use, Lab Use Only.

BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively.
BPR1M97 elicited full agonist properties for all cell-based assays tested in MOP-expressing cells.
BPR1M97 acted as a G protein-biased agonist for NOP.
BPR1M97 initiated faster antinociceptive effects after subcutaneous injection and elicited better analgesia in cancer-induced pain than morphine.
BPR1M97 caused less respiratory, cardiovascular, and gastrointestinal dysfunction, compared with morphine.

Physicochemical Properties

M.Wt 349.25
Formula C18H18Cl2N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,4-Dichloro-N-[(1,2,3,4-tetrahydro-2-methyl-1-isoquinolinyl)methyl]benzamide

References

1. Po-Kuan Chao, et al. Neuropharmacology. 2020 Apr;166:107678.

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