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Chemical Structure : BPRMU191
Catalog No.: PC-22776Not For Human Use, Lab Use Only.
BPRMU191 is a unique mu-opioid receptor (MOR) modulator with EC50 of 2.17 uM in FLIPR Ca2+ assay using CHO-K1/MOR/Gα15 cells, BPRMU191 binds to MOR in the presence of naloxone.
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BPRMU191 is a unique mu-opioid receptor (MOR) modulator with EC50 of 2.17 uM in FLIPR Ca2+ assay using CHO-K1/MOR/Gα15 cells, BPRMU191 binds to MOR in the presence of naloxone.
BPRMU191 interacts with ECL2 (extracellular loop 2) of MOR.
BPRMU191 exemplifies an antagonist-to-agonist modulator of mu-opioid receptor (MOR).
BPRMU191 converts opioid antagonists to G protein-biased agonists of MOR.
Co-application of BPRMU191 and morphinan antagonists resulted in MOR-dependent analgesia with diminished side effects, including gastrointestinal dysfunction, antinociceptive tolerance, and physical and psychological dependence.
BPRMU191/naltrexone produces antinociceptive effects in mouse models of clinical pain.
| M.Wt | 331.36 | |
| Formula | C17H14FNO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang YH, et al. Cell Chem Biol. 2024 Jul 9:S2451-9456(24)00272-1.
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