BR-cpd7 | FGFR1/2 degrader | Probechem Biochemicals

Chemical Structure : BR-cpd7

BR-cpd7 (FGFR1/2 PROTAC BR-cpd7)

Catalog No.: PC-22214Not For Human Use, Lab Use Only.

BR-cpd7 is a potent, selective FGFR1/2-targeting proteolysis targeting chimeric (PROTAC) degrader with DC50 of 10 nM, while sparing FGFR3.

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Biological Activity

BR-cpd7 is a potent, selective FGFR1/2-targeting proteolysis targeting chimeric (PROTAC) degrader with DC50 of 10 nM, while sparing FGFR3.
BR-cpd7 induces cell cycle arrest and consequently blocks the proliferation of multiple FGFR1/2-dependent tumor cells.
BR-cpd7 shows no anti-proliferative activity against cancer cells without FGFR aberrations.
BR-cpd7 exhibits robust antitumor effects in FGFR1-dependent lung cancer at well-tolerated dose schedules, accompanied by complete FGFR1 depletion in vivo.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

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BR-cpd7 (FGFR1/2 PROTAC BR-cpd7)

Biological Activity

Physicochemical Properties

References

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