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BRAF inhibitor 13

Chemical Structure : BRAF inhibitor 13

CAS No.: 1093100-40-3

BRAF inhibitor 13 (BRAF-IN-13)

Catalog No.: PC-70025Not For Human Use, Lab Use Only.

A potent and selective B-Raf inhibitor with IC50 of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively.

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Biological Activity

BRAF inhibitor 13 (BRAF-IN-13) is a potent and selective B-Raf inhibitor with IC50 of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively.
BRAF inhibitor 13 (BRAF-IN-13) induces proliferation and hyperplasia in normal tissues of mice.

Physicochemical Properties

M.Wt 478.944
Formula C26H19ClN8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N5-(3-(9H-purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

References

1. Wang X, et al. J Med Chem. 2012 Sep 13;55(17):7332-41.

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