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BRD-810

Chemical Structure : BRD-810

CAS No.: 2329720-10-5

BRD-810 (BRD810)

Catalog No.: PC-22977Not For Human Use, Lab Use Only.

BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein.
BRD-810 shows no appreciable off-target binding versus a broad panel of enzymes, receptors and ion channels.
BRD-810-induced cell death indeed occurs through an on-target mechanism activating the intrinsic apoptotic pathway.
BRD-810 (25-50 mg/kg, intravenously injected once weekly) shows robust antitumor effects in monotherapy AMO-1 (multiple myeloma) tumor-bearing mice.

Physicochemical Properties

M.Wt 702.26
Formula C40H45ClFN3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-13-chloro-12-ethyl-1-(3-((6-fluoronaphthalen-1-yl)oxy)propyl)-11-methyl-9-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5,6,7,9,11-hexahydropyrazolo[4',3':9,10][1]oxa[6]azacycloundecino[8,7,6-hi]indole-2-carboxylic acid

References

1. Rauh U, et al. Nat Cancer. 2024 Aug 23. doi: 10.1038/s43018-024-00814-0.

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