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Chemical Structure : BRD-810
Catalog No.: PC-22977Not For Human Use, Lab Use Only.
BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein.
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BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein.
BRD-810 shows no appreciable off-target binding versus a broad panel of enzymes, receptors and ion channels.
BRD-810-induced cell death indeed occurs through an on-target mechanism activating the intrinsic apoptotic pathway.
BRD-810 (25-50 mg/kg, intravenously injected once weekly) shows robust antitumor effects in monotherapy AMO-1 (multiple myeloma) tumor-bearing mice.
| M.Wt | 702.26 | |
| Formula | C40H45ClFN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rauh U, et al. Nat Cancer. 2024 Aug 23. doi: 10.1038/s43018-024-00814-0.
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