Chemical Structure : BRD-810
CAS No.:
2329720-10-5
BRD-810
(BRD810)
Catalog No.: PC-22977Not For Human Use, Lab Use Only.
BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BRD-810 is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein.
BRD-810 shows no appreciable off-target binding versus a broad panel of enzymes, receptors and ion channels.
BRD-810-induced cell death indeed occurs through an on-target mechanism activating the intrinsic apoptotic pathway.
BRD-810 (25-50 mg/kg, intravenously injected once weekly) shows robust antitumor effects in monotherapy AMO-1 (multiple myeloma) tumor-bearing mice.
Physicochemical Properties
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M.Wt
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702.26
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Formula
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C40H45ClFN3O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-13-chloro-12-ethyl-1-(3-((6-fluoronaphthalen-1-yl)oxy)propyl)-11-methyl-9-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5,6,7,9,11-hexahydropyrazolo[4',3':9,10][1]oxa[6]azacycloundecino[8,7,6-hi]indole-2-carboxylic acid
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References
1. Rauh U, et al. Nat Cancer. 2024 Aug 23. doi: 10.1038/s43018-024-00814-0.
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