BRD1991 | Beclin 1/Bcl-2 inhibitor | Probechem Biochemicals

Chemical Structure : BRD1991

BRD1991 (BRD-1991)

Catalog No.: PC-35318Not For Human Use, Lab Use Only.

BRD1991 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity.

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Biological Activity

BRD1991 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity.

Physicochemical Properties

M.Wt	608.56
Formula	C33H35Cl2N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-dichloro-N-((10-(1-hydroxypropan-2-yl)-8,12-dimethyl-11-oxo-7,8,9,10,11,12-hexahydro-5H-benzo[9,10][1]oxa[5]azacycloundecino[7,8-b]indol-7-yl)methyl)-N-methylbenzamide

References

1. Chiang WC, et al. ACS Chem Biol. 2018 Jun 21. doi: 10.1021/acschembio.8b00421.

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BRD1991 (BRD-1991)

Biological Activity

Physicochemical Properties

References

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