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BRD2492

Chemical Structure : BRD2492

CAS No.: 1821669-43-5

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BRD2492 (BRD 2492)

Catalog No.: PC-62400Not For Human Use, Lab Use Only.

BRD2492 is a highly potent, selective HDAC1/2 inhibitor (IC50=2/19 nM, respectively) that displays excellent selectivity versus HDAC3 (IC50=2.08 uM, ≥110-fold selectivity) and all other HDAC isoforms, increases caspase-3 activation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BRD2492 is a highly potent, selective HDAC1/2 inhibitor (IC50=2/19 nM, respectively) that displays excellent selectivity versus HDAC3 (IC50=2.08 uM, ≥110-fold selectivity) and all other HDAC isoforms, increases caspase-3 activation.

Physicochemical Properties

M.Wt 346.39
Formula C20H18N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Acetylamino-N-(2-amino-5-pyridin-4-yl-phenyl)-benzamide

References

1. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74.

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