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BRD2879

Chemical Structure : BRD2879

CAS No.: 1304750-47-7

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BRD2879 (BRD-2879;BRD 2879)

Catalog No.: PC-35209Not For Human Use, Lab Use Only.

BRD2879 (BRD-2879) is a potent, selective inhibitor of IDH1-R132H mutant with IC50 of 50 nM, inhibits cell-based production of R-2HG with EC50 of 0.3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD2879 (BRD-2879) is a potent, selective inhibitor of IDH1-R132H mutant with IC50 of 50 nM, inhibits cell-based production of R-2HG with EC50 of 0.3 uM.
    BRD2879 shows weak inhibition against IDH1-R132C (IC50=2.5 uM), and no activity against IDH1-WT and IDH2-R140Q (IC50>20 uM).
    BRD2879 displays competitive patterns with both the α-KG substrate and the Mg2+ cofactor.

    Physicochemical Properties

    M.Wt 571.708
    Formula C30H38FN3O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-cyclohexyl-1-(((4R,5R)-8-((3-fluorophenyl)ethynyl)-2-((S)-1-hydroxypropan-2-yl)-4-methyl-1,1-dioxido-2,3,4,5-tetrahydrobenzo[b][1,4,5]oxathiazocin-5-yl)methyl)-1-methylurea

    References

    1. Law JM, et al. ACS Med Chem Lett. 2016 Aug 18;7(10):944-949.

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