BRD4310a

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Chemical Structure : BRD4310a

Catalog No.: PC-25769Not For Human Use, Lab Use Only.

BRD4310a is a potent, small molecule inhibitor of QcrB inhibitor with MIC of 5.7 uM against wild-type Mtb strain H37Rv.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BRD4310a is a potent, small molecule inhibitor of QcrB inhibitor with MIC of 5.7 uM against wild-type Mtb strain H37Rv.
BRD4310a demonstrates activity against M. bovis bacille Calmette–Guerin (BCG), and M. marinum, but not M. smegmatis, M. fortuitum, or M.abscessus or gram-positive Staphylococcus aureus and Enterococcus faecalis or gram-negative Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa.
BRD4310a triggers rapid intracellular ATP reduction, similar to the effect of exposure to Q203 (Cat#PC-42302).

Physicochemical Properties

M.Wt	292.39
Formula	C18H20N4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(4-methylbenzyl)-4-(pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine

References

1. Bond AN, et al. Nat Commun. 2025 Nov 3;16(1):9673.

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BRD4310a

Biological Activity

Physicochemical Properties

References

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