BRD5631 |CAS:2446154-91-0 Probechem Biochemicals

Chemical Structure : BRD5631

BRD5631 (BRD 5631;BRD-5631)

Catalog No.: PC-70317Not For Human Use, Lab Use Only.

BRD5631 is a small-molecule enhancer of autophagy through an mTOR-independent pathway.

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Biological Activity

BRD5631 is a small-molecule enhancer of autophagy through an mTOR-independent pathway.
BRD5631 significantly reduces the number of eGFP-HDQ74-positive cells, and increases the transcript level of p62 in Atg5+/+ MEFs.
BRD5631 significantly reduces levels of endogenous p62 and cell death in NPC1 hiPSC-derived neurons.
BRD5631 enhances bacterial clearance and suppresses IL-1β Secretion in an autophagy-dependent manner.
BRD5631 is a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease.

Physicochemical Properties

M.Wt	501.627
Formula	C30H35N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((3S,6S,7S)-7-methoxy-3,6,9-trimethyl-10-oxo-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1]oxa[4,9]diazacyclododecin-12-yl)-[1,1'-biphenyl]-4-carboxamide

References

1. Kuo SY, et al. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4281-7.

BRD5631 (BRD 5631;BRD-5631)

Biological Activity

Physicochemical Properties

References

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