BRD7116 | HMGCR inhibitor | Probechem Biochemicals

Chemical Structure : BRD7116

CAS No.: 329059-55-4

BRD7116 (BRD-7116)

Catalog No.: PC-45539Not For Human Use, Lab Use Only.

BRD7116 selective inhibitor of leukemia stem cells (LSCs) via inhibition of HMG-CoA reductase (HMGCR).

Packing	Price	Stock
10 mg	$88	In stock
25 mg	$138	In stock
50 mg	$228	In stock
100 mg	$398	In stock
250 mg		Get quote

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Biological Activity

BRD7116 selective inhibitor of leukemia stem cells (LSCs) via inhibition of HMG-CoA reductase (HMGCR).
BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture.
BRD7116 shows limited activity against normal HSPCs and AML cell lines (>10 uM).

Physicochemical Properties

M.Wt	496.6614
Formula	C28H36N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 48 mg/mL
Chemical Name/SMILES	Cyclopropanecarboxamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl- (9CI)

References

1. Hartwell KA, et al. Nat Chem Biol. 2013 Dec;9(12):840-8.

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BRD7116 (BRD-7116)

Biological Activity

Physicochemical Properties

References

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