BRD 7389 is an inhibitor of ribosomal S6 kinases (RSK) with IC50 of 1.5 uM, 2.4 uM, and 1.2 uM for RSK1, RSK2, and RSK3, respectively.
BRD 7389 inhibits not only RSK enzymes, but also members of several other kinase families.
BRD 7389 causes alpha-cells to adopt several morphological and gene expression features of a beta-cell state.
BRD 7389 also blockes carbachol-stimulated cell proliferation in SNU-407 cells.
