BRD7389 is an inhibitor of ribosomal S6 kinases (RSK) with IC50 of 1.5 uM, 2.4 uM, and 1.2 uM for RSK1, RSK2, and RSK3, respectively.
BRD7389 inhibits not only RSK enzymes, but also members of several other kinase families.
BRD7389 causes alpha-cells to adopt several morphological and gene expression features of a beta-cell state.
BRD7389 also blockes carbachol-stimulated cell proliferation in SNU-407 cells.
