BRD7586 | SpCas9 inhibitor | Probechem Biochemicals

Chemical Structure : BRD7586

CAS No.: 895460-70-5

BRD7586 (BRD 7586)

Catalog No.: PC-49532Not For Human Use, Lab Use Only.

BRD7586 (BRD 7586) is a potent, cell-permeable small-molecule inhibitor of SpCas9 with Kd value of 0.52 uM.

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10 mg	$198	In stock
25 mg	$298	In stock
50 mg	$458	In stock
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Biological Activity

BRD7586 (BRD 7586) is a potent, cell-permeable small-molecule inhibitor of SpCas9 with Kd value of 0.52 uM.
BRD7586 enhanced SpCas9 specificity and its activity was independent of the genomic loci, DNA-repair pathway or mode of nuclease delivery.

Physicochemical Properties

M.Wt	407.887
Formula	C17H14ClN3O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-chlorophenyl)sulfonyl)-N-(4-(pyridin-4-yl)thiazol-2-yl)propanamide

References

1. Donghyun Lim, et al. Nat Cell Biol. 2022 Nov 17. doi: 10.1038/s41556-022-01005-8.

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BRD7586 (BRD 7586)

Biological Activity

Physicochemical Properties

References

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