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BRD7586

Chemical Structure : BRD7586

CAS No.: 895460-70-5

BRD7586 (BRD 7586)

Catalog No.: PC-49532Not For Human Use, Lab Use Only.

BRD7586 (BRD 7586) is a potent, cell-permeable small-molecule inhibitor of SpCas9 with Kd value of 0.52 uM.

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Biological Activity

BRD7586 (BRD 7586) is a potent, cell-permeable small-molecule inhibitor of SpCas9 with Kd value of 0.52 uM.
BRD7586 enhanced SpCas9 specificity and its activity was independent of the genomic loci, DNA-repair pathway or mode of nuclease delivery.

Physicochemical Properties

M.Wt 407.887
Formula C17H14ClN3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((4-chlorophenyl)sulfonyl)-N-(4-(pyridin-4-yl)thiazol-2-yl)propanamide

References

1. Donghyun Lim, et al. Nat Cell Biol. 2022 Nov 17. doi: 10.1038/s41556-022-01005-8.

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