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Chemical Structure : BRD9 PROTAC C6
Catalog No.: PC-23329Not For Human Use, Lab Use Only.
BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7.
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BRD9 PROTAC C6 is a potent, selective and orally active BRD9 PROTAC degrader with DC50 of 1.02 nM in MV4-11 cells (24 h), without effect on BRD4 or BRD7.
C6 has IC50 value of 3.69 ± 3.58 nM in MV4-11 CTRL cells.
C6 exhibited significantly oral activity in ICR mice with the Cmax value of 3436.95 ng/mL.
| M.Wt | 649.70 | |
| Formula | C36H35N5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang J, et al. Eur J Med Chem. 2023 Oct 17;262:115872.
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