Chemical Structure : BRD9 degrader ZZ7
CAS No.:
BRD9 degrader ZZ7
Catalog No.: PC-25575Not For Human Use, Lab Use Only.
BRD9 degrader ZZ7 is a specific, reversible covalent molecular glue degrader that selectively degrades BRD9, covalently engages DCAF16 at Cys178.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BRD9 degrader ZZ7 is a specific, reversible covalent molecular glue degrader that selectively degrades BRD9, covalently engages DCAF16 at Cys178.
ZZ7 is a proteasomal pathway-dependent BRD9 molecular glue degrader.
ZZ7 recruits DCAF16 to induce the degradation of BRD9. induces selective degradation of BRD9 in synovial sarcoma cells, with minimal effect on human iPSC-derived cardiomyocytes.
ZZ7 shows antiproliferative activity synovial sarcoma cell lines HS-SY-II and 1273/99 with IC50 of 322 nM and 426 nM respectively.
ZZ7 induces tissue-specific BRD9 degradation, resulting in a potent and selective antiproliferative effect against synovial sarcoma cells while potentially avoiding the cardiac side effects associated with clinical-stage BRD9 degraders.
Physicochemical Properties
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M.Wt
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655.80
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Formula
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C36H45N7O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-2-(4-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazine-1-carbonyl)-4-methyl-4-(4-(oxetan-3-yl)piperazin-1-yl)pent-2-enenitrile
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References
1. Byun WS, et al. J Am Chem Soc. 2025 Sep 17. doi: 10.1021/jacs.5c09857.
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