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BRL-44408

Chemical Structure : BRL-44408

CAS No.: 118343-19-4

BRL-44408 (BRL44408)

Catalog No.: PC-60702Not For Human Use, Lab Use Only.

BRL-44408 is a potent, selective α2A-adrenoceptor antagonist with Ki of 1.7 nM, 80-fold selectivity over α2B-adrenergic receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRL-44408 is a potent, selective α2A-adrenoceptor antagonist with Ki of 1.7 nM, 80-fold selectivity over α2B-adrenergic receptors.
    BRL-44408 significantly increases stimulated noradrenaline release in rat locus coeruleus slices at 0.1-1 uM, significantly increases the electrically induced release in rats.

    Physicochemical Properties

    M.Wt 215.3
    Formula C13H17N3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,3-dihydro-1-methyl-1H-isoindole

    References

    1. Kiss JP, et al. Brain Res. 1995 Mar 20;674(2):238-44.

    2. Callado LF, et al. Eur J Pharmacol. 1999 Jan 29;366(1):35-9.

    3. Young P, et al. Eur J Pharmacol. 1989 Sep 22;168(3):381-6.

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