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Chemical Structure : BRL-44408 maleate
CAS No.: 681806-46-2
Catalog No.: PC-60703Not For Human Use, Lab Use Only.
BRL-44408 maleate is a potent, selective α2A-adrenoceptor antagonist with Ki of 1.7 nM, 80-fold selectivity over α2B-adrenergic receptors.
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BRL-44408 maleate is a potent, selective α2A-adrenoceptor antagonist with Ki of 1.7 nM, 80-fold selectivity over α2B-adrenergic receptors.
BRL-44408 maleate significantly increases stimulated noradrenaline release in rat locus coeruleus slices at 0.1-1 uM, significantly increases the electrically induced release in rats.
| M.Wt | 331.372 | |
| Formula | C17H21N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate |
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1. Kiss JP, et al. Brain Res. 1995 Mar 20;674(2):238-44.
2. Callado LF, et al. Eur J Pharmacol. 1999 Jan 29;366(1):35-9.
3. Young P, et al. Eur J Pharmacol. 1989 Sep 22;168(3):381-6.
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