You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-BRL-50481
BRL-50481

Chemical Structure : BRL-50481

CAS No.: 433695-36-4

BRL-50481 (BRL50481, BRL 50481)

Catalog No.: PC-61339Not For Human Use, Lab Use Only.

BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5.

Packing Price Stock Quantity
10 mg $58 In stock
25 mg $98 In stock
100 mg $198 In stock
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5.
BRL-50481 inhibits TNFalpha generation, demonstrates pharmacological activity on proinflammatory responses in human blood monocytes, lung macrophages, and CD8+ T-lymphocytes.
BRL-50481 induces anxiolytic and anorexigenic like behavior in rats.

Physicochemical Properties

M.Wt 244.267
Formula C9H12N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N,2-Trimethyl-5-nitrobenzenesulfonamide

References

1. Smith SJ, et al. Mol Pharmacol. 2004 Dec;66(6):1679-89.

2. Pekkinen M, et al. Bone. 2008 Jul;43(1):84-91.

3. Valdés-Moreno MI, et al. Behav Brain Res. 2017 Feb 15;319:165-173.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: