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BRL-50481

Chemical Structure : BRL-50481

CAS No.: 433695-36-4

BRL-50481 (BRL50481;BRL 50481)

Catalog No.: PC-61339Not For Human Use, Lab Use Only.

BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5.
BRL-50481 inhibits TNFalpha generation, demonstrates pharmacological activity on proinflammatory responses in human blood monocytes, lung macrophages, and CD8+ T-lymphocytes.
BRL-50481 induces anxiolytic and anorexigenic like behavior in rats.

Physicochemical Properties

M.Wt 244.267
Formula C9H12N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N,2-Trimethyl-5-nitrobenzenesulfonamide

References

1. Smith SJ, et al. Mol Pharmacol. 2004 Dec;66(6):1679-89.

2. Pekkinen M, et al. Bone. 2008 Jul;43(1):84-91.

3. Valdés-Moreno MI, et al. Behav Brain Res. 2017 Feb 15;319:165-173.

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