BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5.
BRL-50481 inhibits TNFalpha generation, demonstrates pharmacological activity on proinflammatory responses in human blood monocytes, lung macrophages, and CD8+ T-lymphocytes.
BRL-50481 induces anxiolytic and anorexigenic like behavior in rats.
Physicochemical Properties
M.Wt
244.267
Formula
C9H12N2O4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N,N,2-Trimethyl-5-nitrobenzenesulfonamide
References
1. Smith SJ, et al. Mol Pharmacol. 2004 Dec;66(6):1679-89.
2. Pekkinen M, et al. Bone. 2008 Jul;43(1):84-91.
3. Valdés-Moreno MI, et al. Behav Brain Res. 2017 Feb 15;319:165-173.
