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Chemical Structure : BRL54443
CAS No.: 57477-39-1
Catalog No.: PC-43401Not For Human Use, Lab Use Only.
BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.
BRL54443 shows low affinity for other receptors 5-HT1A (63 nM), 5-HT1B (126 nM), 5-HT1D (63 nM), 5-HT2A (1259 nM), 5-HT2B (100 nM), 5-HT2C (316 nM), 5-HT6 (>10,000 nM), 5-HT7 (>10,000 nM), D2 (501 nM), D3 (631 nM), and α1B-adrenoceptors (1259 nM).
BRL54443 selectively stimulates 5-HT1E receptors and potently inhibits forskolin-dependent cAMP production with IC50 of 14 nM in DG membranes.
BRL54443 significantly reduces formalin-induced flinching in rats.
| M.Wt | 230.3055 | |
| Formula | C14H18N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 51 mg/mL |
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| Chemical Name/SMILES |
1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)- |
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1. Klein MT, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7.
2. Klein MT,et al. Br J Pharmacol. 2012 Jun;166(4):1290-302.
3. Granados-Soto V, et al. Neuroscience. 2010 Jan 20;165(2):561-8.
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