BRL54443 | 5-HT1E/1F agonist | Probechem Biochemicals

Chemical Structure : BRL54443

CAS No.: 57477-39-1

BRL54443 (BRL 54443, BRL-54443)

Catalog No.: PC-43401Not For Human Use, Lab Use Only.

BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.

Packing	Price	Stock
10 mg	$78	In stock
25 mg	$128	In stock
50 mg	$198	In stock
100 mg	$298	In stock
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.
BRL54443 shows low affinity for other receptors 5-HT1A (63 nM), 5-HT1B (126 nM), 5-HT1D (63 nM), 5-HT2A (1259 nM), 5-HT2B (100 nM), 5-HT2C (316 nM), 5-HT6 (>10,000 nM), 5-HT7 (>10,000 nM), D2 (501 nM), D3 (631 nM), and α1B-adrenoceptors (1259 nM).
BRL54443 selectively stimulates 5-HT1E receptors and potently inhibits forskolin-dependent cAMP production with IC50 of 14 nM in DG membranes.
BRL54443 significantly reduces formalin-induced flinching in rats.

Physicochemical Properties

M.Wt	230.3055
Formula	C14H18N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 51 mg/mL
Chemical Name/SMILES	1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-

References

1. Klein MT, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7.

2. Klein MT,et al. Br J Pharmacol. 2012 Jun;166(4):1290-302.

3. Granados-Soto V, et al. Neuroscience. 2010 Jan 20;165(2):561-8.

BRL54443 (BRL 54443, BRL-54443)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.