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BRL54443

Chemical Structure : BRL54443

CAS No.: 57477-39-1

BRL54443 (BRL 54443, BRL-54443)

Catalog No.: PC-43401Not For Human Use, Lab Use Only.

BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BRL54443 is a potent, releative selective 5-HT1E/1F agonist with Ki of 2/1 nM, respectively.
BRL54443 shows low affinity for other receptors 5-HT1A (63 nM), 5-HT1B (126 nM), 5-HT1D (63 nM), 5-HT2A (1259 nM), 5-HT2B (100 nM), 5-HT2C (316 nM), 5-HT6 (>10,000 nM), 5-HT7 (>10,000 nM), D2 (501 nM), D3 (631 nM), and α1B-adrenoceptors (1259 nM).
BRL54443 selectively stimulates 5-HT1E receptors and potently inhibits forskolin-dependent cAMP production with IC50 of 14 nM in DG membranes.
BRL54443 significantly reduces formalin-induced flinching in rats.

Physicochemical Properties

M.Wt 230.3055
Formula C14H18N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 51 mg/mL

Chemical Name/SMILES

1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-

References

1. Klein MT, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7.

2. Klein MT,et al. Br J Pharmacol. 2012 Jun;166(4):1290-302.

3. Granados-Soto V, et al. Neuroscience. 2010 Jan 20;165(2):561-8.

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