BSJ-03-204 | CDK4/6 degrader | Probechem Biochemicals

Chemical Structure : BSJ-03-204

CAS No.: 2349356-09-6

BSJ-03-204 (CDK4/6 PROTAC)

Catalog No.: PC-73288Not For Human Use, Lab Use Only.

BSJ-03-204 is a dual and selective degrader (PROTAC) of CDK4 and CDK6 with IC50 of 26.9 nM and 10.4 nM for CDK4/D1 and CDK6/D1, respectively, does not induce IKZF1/3 degradation.

Packing	Price	Stock
5 mg	$248	In stock
10 mg	$388	In stock
25 mg	$598	In stock
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Biological Activity

BSJ-03-204 is a dual and selective degrader (PROTAC) of CDK4 and CDK6 with IC50 of 26.9 nM and 10.4 nM for CDK4/D1 and CDK6/D1, respectively, does not induce IKZF1/3 degradation.

Physicochemical Properties

M.Wt	832.91
Formula	C43H48N10O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)butyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

References

1. Baishan Jiang, et al. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326.

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BSJ-03-204 (CDK4/6 PROTAC)

Biological Activity

Physicochemical Properties

References

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