BT-114143 | Plasminogen activation inhibitor

Chemical Structure : BT-114143

BT-114143 (BT114143)

Catalog No.: PC-24262Not For Human Use, Lab Use Only.

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Biological Activity

BT-114143 is a small molecule plasminogen activation inhibitor with IC50 of 7.42 uM in in vitro enzymatic reaction system (buffer clot lysis assay), and IC50 of 0.56 uM for fibrinolysis in human whole blood.
BT-114143 exhibits superior activity in inhibiting fibrinolysis compared to tranexamic acid (TXA).
BT-114143 significantly reduced the tail bleeding time at dosages of 5 mg/kg/h and 40 mg/kg/h in rat model.

Physicochemical Properties

M.Wt	250.62
Formula	C8H12ClN2O3P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(5,6,7,8-Tetrahydro-1,6-naphthyridin-2-yl)phosphonic Acid Hydrochloride

References

1. Ji S, et al. J Med Chem. 2025 Mar 18. doi: 10.1021/acs.jmedchem.4c03190.

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BT-114143 (BT114143)

Biological Activity

Physicochemical Properties

References

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