Chemical Structure : BT-O2C
CAS No.:
3055107-34-8
BT-O2C
(p300 degrader)
Catalog No.: PC-24242Not For Human Use, Lab Use Only.
BT-O2C is a potent, selective PROTAC degrader of p300, potently degrades p300 while sparing CBP, is cytotoxic in CIC::DUX4 sarcoma (CDS) cell lines (IC50=152-221 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BT-O2C is a potent, selective PROTAC degrader of p300, potently degrades p300 while sparing CBP, is cytotoxic in CIC::DUX4 sarcoma (CDS) cell lines (IC50=152-221 nM).
BT-O2C is mechanistically dependent on both neddylation to activate the CUL4CRBN and on proteasome activity.
BT-O2C significantly reduces expression of CIC::DUX4 target genes ETV1, ETV4 and ETV5.
Physicochemical Properties
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M.Wt
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973.96
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Formula
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C48H48F5N9O8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((3'R,4S)-5'-(1-(2-((7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)heptyl)amino)-2-oxoethyl)-1H-pyrazol-4-yl)-3'-fluoro-2,5-dioxo-2',3'-dihydrospiro[imidazolidine-4,1'-inden]-1-yl)-N-(4-fluorobenzyl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide
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References
1. Marsh GP, et al. RSC Med Chem. 2025 Mar 3. doi: 10.1039/d4md00969j.
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