Catalog No.: PC-24242Not For Human Use, Lab Use Only.
BT-O2C is a potent, selective PROTAC degrader of p300, potently degrades p300 while sparing CBP, is cytotoxic in CIC::DUX4 sarcoma (CDS) cell lines (IC50=152-221 nM).
BT-O2C is a potent, selective PROTAC degrader of p300, potently degrades p300 while sparing CBP, is cytotoxic in CIC::DUX4 sarcoma (CDS) cell lines (IC50=152-221 nM).
BT-O2C is mechanistically dependent on both neddylation to activate the CUL4CRBN and on proteasome activity.
BT-O2C significantly reduces expression of CIC::DUX4 target genes ETV1, ETV4 and ETV5.
