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Chemical Structure : BTB09089
CAS No.: 245728-44-3
Catalog No.: PC-49199Not For Human Use, Lab Use Only.
BTB09089 (BTB 09089) is a specific small molecule agonist of T cell death-associated gene 8 (TDAG8, GPR65).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $558 | In stock | |
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| 100 mg | Get quote |
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BTB09089 (BTB 09089) is a specific small molecule agonist of T cell death-associated gene 8 (TDAG8, GPR65).
BTB09089 does not act on other proton sensing G-protein-coupled receptors such as G-protein-coupled receptor 4 (GPR4) nor ovarian cancer G-protein-coupled receptor 1 (OGR1).
BTB09089 increased cAMP level in the splenocytes from wild-type littermates but not from TDAG8-deficient mice.
BTB09089 suppressed the production of IL-2 stimulated with anti-CD3 and anti-CD28 antibodies in splenocytes.
BTB09089 suppressed the production of TNF-α and IL-6 while it increased that of IL-10 when stimulated with lipopolysaccharide, in peritoneal exuded macrophages induced by thioglycollate.
BTB09089 attenuated immune-mediated inflammation by regulating the cytokine production of T cells and macrophages.
| M.Wt | 387.297 | |
| Formula | C14H12Cl2N4OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-1H-pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one |
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1. Onozawa Y, et al. Eur J Pharmacol. 2012 May 15;683(1-3):325-31.
2. Ma XD, et al. Exp Neurol. 2017 Jul;293:115-123.
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