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BTC-8

Chemical Structure : BTC-8

CAS No.:

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BTC-8 (BTC 8;BTC8)

Catalog No.: PC-60923Not For Human Use, Lab Use Only.

BTC-8 is a derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BTC-8 is a derivative of BAM-7 that acts as a nove potent, direct activator of Bax with EC50 of 700 nM.
    BTC-8 inhibits GBM cell proliferation, arrests the cell cycle, and induces apoptosis through the induction of mitochondrial membrane permeabilization.
    BTC-8 also blocks proliferation and self-renewal of GSCs and induces their apoptosis; sensitizes both GBM cells and GSCs to the alkylating agent Temozolomide.

    Physicochemical Properties

    M.Wt 457.534
    Formula C26H27N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-2-(4'-(dimethylamino)-2-hydroxy-[1,1'-biphenyl]-4-yl)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

    References

    1. Daniele S, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114.

    2. Stornaiuolo M, et al. J Med Chem. 2015 Mar 12;58(5):2135-48.

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