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BTK-IN-23

Chemical Structure : BTK-IN-23

CAS No.: 1227206-13-4

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BTK-IN-23 (BTK inhibitor 23)

Catalog No.: PC-62701Not For Human Use, Lab Use Only.

BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM.
    BTK-IN-23 displays 5-fold and 77-fold selectivity over BMX and TEC, >300-fold selectivity over FGR, SRC and MELK.
    BTK-IN-23 demonstrates potent inhibition of anti-IgE stimulated CD63 expression on basophils, with an EC50 of 257 nM.
    BTK-IN-23 shows improved stability compared to GDC-0834.

    Physicochemical Properties

    M.Wt 529.594
    Formula C27H24FN7O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(6-fluoro-2-methyl-3-(5-((5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino)-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)benzo[b]thiophene-2-carboxamide

    References

    1. Young WB, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):575-9.

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