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BTK PROTAC 10

Chemical Structure : BTK PROTAC 10

CAS No.: 2250382-66-0

BTK PROTAC 10

Catalog No.: PC-35425Not For Human Use, Lab Use Only.

BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells.
    BTK PROTAC 10 can successfully delivered to tissues and can specifically degrade BTK in vivo, in a dose-dependent and tissue-biased manner by s.c. administration.

    Physicochemical Properties

    M.Wt 976.989
    Formula C47H54F2N8O13
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    17-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1Hisoindol-4-yl]amino}-3,6,9,12,15-pentaoxaheptadec-1-yl(3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate

    References

    1. Zorba A, et al. Proc Natl Acad Sci U S A. 2018 Jul 16. pii: 201803662.

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