BTK PROTAC degrader 3

Chemical Structure : BTK PROTAC degrader 3

Catalog No.: PC-22861Not For Human Use, Lab Use Only.

BTK PROTAC degrader 3 is a potent BTK degrader with DC50 value of 10.9 nM in Mino cells, shows potential for B-cell malignancies, including chronic lymphoid malignancies.

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Biological Activity

BTK PROTAC degrader 3 is a potent BTK degrader with DC50 value of 10.9 nM in Mino cells, shows potential for B-cell malignancies, including chronic lymphoid malignancies.

Physicochemical Properties

M.Wt	752.82
Formula	C41H40N10O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[3-[4-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3′-biazetidin]-1′-yl]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

References

1. Zhangchen, et al. Salt of compound for degrading btk, crystal form thereof, and use thereof in medicine. Patent WO2022052950A1.

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