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Chemical Structure : BTRX-335140
CAS No.: 2244614-14-8
Catalog No.: PC-36056Not For Human Use, Lab Use Only.
BTRX-335140 (CYM-53093, BTRX335140, CYM53093) is a potent, selective, orally active κ opioid receptor (KOR) antagonist with IC50 of 0.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | $1380 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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BTRX-335140 (Navacaprant, CYM-53093, BTRX335140, CYM53093) is a potent, selective, orally active κ opioid receptor (KOR) antagonist with IC50 of 0.8 nM.
BTRX-335140 displays >100-fold selectivity over MOR and DOR.
BTRX-335140 demonstrates favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments, shows robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice.
| M.Wt | 453.562 | |
| Formula | C25H32FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4 amine |
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1. Guerrero M, et al. J Med Chem. 2019 Feb 1. doi: 10.1021/acs.jmedchem.8b01679.
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