Chemical Structure : BTX-1188
Catalog No.: PC-23063Not For Human Use, Lab Use Only.
Sontigidomide (BTX-1188) is a first-in-class dual degrader of GSPT1 and IKZF1/3 with DC50 of 0.2 nM, 1 nM and 1 nM for GSPT1, IKZF1 and IKZF3 respectively, in DOHH-2 (lymphoma) cells.
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Sontigidomide (BTX-1188) is a first-in-class dual degrader of GSPT1 and IKZF1/3 with DC50 of 0.2 nM, 1 nM and 1 nM for GSPT1, IKZF1 and IKZF3 respectively, in DOHH-2 (lymphoma) cells.
BTX-1188 potently inhibits AML and solid tumor cell proliferation.
Sontigidomide (BTX-1188) potently inhibits aCD3-stimulated and LPS-induced cytokine induction in human PBMCs.
BTX-1188 is cytotoxic in various cancer cell lines such as MYC-dependent and non-MYC dependent lines (IC50 range: 0.5-20 nM) and primary human AML patient samples (IC50 range: 0.4-1.5 nM), including relapsed/refractory-, cytarabine and Venetoclax-resistant samples.
BTX-1188 (25 mg/kg, i.p. QD) is highly efficacious in NCI H1155 (NSCLC) xenograft model in BALB/c nude mice.
M.Wt | 513.47 | |
Formula | C26H22F3N3O5 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Patent US20200369679 A1
2. Aparajita Hoskote Chourasia, et al. Meeting Abstract: 2022 ASCO Annual Meeting I
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