BTX-6654 | SOS1 PROTAC degrader | Probechem Biochemicals

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Chemical Structure : BTX-6654

BTX-6654 (BTX6654)

Catalog No.: PC-21882Not For Human Use, Lab Use Only.

BTX-6654 is a potent, selective SOS1 cereblon-based bifunctional PROTAC degrader, reduces downstream signaling markers, pERK and pS6, and displayed antiproliferative activity in cells harboring various KRAS mutations.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	940.06
Formula	C50H57F4N9O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-fluoro-5-(1-(3-(4-(4-(1-methyl-4-(((R)-1-(2-methyl-3-(trifluoromethyl)phenyl)ethyl)amino)phthalazin-6-yl)piperazine-1-carbonyl)piperidin-1-yl)-3-oxopropyl)piperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Kyle Begovich, et al. Mol Cancer Ther. 2024 Jan 15. doi: 10.1158/1535-7163.MCT-23-0513.

2. Johnson JK, et al. ACS medicinal chemistry letters 2016;7(8):785–90

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BTX-6654 (BTX6654)

Biological Activity

Physicochemical Properties

References

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