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Chemical Structure : BTX-6654
Catalog No.: PC-21882Not For Human Use, Lab Use Only.
BTX-6654 is a potent, selective SOS1 cereblon-based bifunctional PROTAC degrader, reduces downstream signaling markers, pERK and pS6, and displayed antiproliferative activity in cells harboring various KRAS mutations.
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BTX-6654 is a potent, selective SOS1 cereblon-based bifunctional PROTAC degrader, reduces downstream signaling markers, pERK and pS6, and displayed antiproliferative activity in cells harboring various KRAS mutations.
| M.Wt | 940.06 | |
| Formula | C50H57F4N9O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kyle Begovich, et al. Mol Cancer Ther. 2024 Jan 15. doi: 10.1158/1535-7163.MCT-23-0513.
2. Johnson JK, et al. ACS medicinal chemistry letters 2016;7(8):785–90
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