BTX161 |CAS:2052301-24-1 Probechem Biochemicals

Chemical Structure : BTX161

CAS No.: 2052301-24-1

BTX161 (BTX-161)

Catalog No.: PC-35629Not For Human Use, Lab Use Only.

BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53, while stabilizing the p53 antagonist MDM2.

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Biological Activity

BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53, while stabilizing the p53 antagonist MDM2.
BTX161 upregulates all the Wnt targets including MYC and does not affect MDM2 mRNA expression.

Physicochemical Properties

M.Wt	272.304
Formula	C15H16N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(4-methyl-1-oxoisoindolin-2-yl)azepane-2,7-dione

References

1. Minzel W, et al. Cell. 2018 Aug 20. pii: S0092-8674(18)30973-5. doi: 10.1016/j.cell.2018.07.045.

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BTX161 (BTX-161)

Biological Activity

Physicochemical Properties

References

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