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BU09059

Chemical Structure : BU09059

CAS No.: 1541206-05-6

BU09059 (BU 09059, BU-09059)

Catalog No.: PC-35296Not For Human Use, Lab Use Only.

BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively.

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    Biological Activity

    BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively.
    BU09059 is a potent and selective κ-antagonist with pA2 of 8.62, significantly blocks U50,488-induced antinociception in vivo (3 and 10 mg/kg).
    BU09059 demonstrates a shorter duration of κ-antagonist action in vivo.

    Physicochemical Properties

    M.Wt 495.62
    Formula C28H37N3O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    ethyl 2-{[(3R)-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]formamido}-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoate

    References

    1. Casal-Dominguez JJ, et al. Send to ACS Chem Neurosci. 2014 Mar 19;5(3):177-84.

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