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Chemical Structure : BV6
CAS No.: 1001600-56-1
Catalog No.: PC-45046Not For Human Use, Lab Use Only.
BV6 is a small molecule, bivalent IAP antagonist that binds to the c-IAP1 and XIAP BIR2-BIR3 domains with Kd of 0.46 and 0.029 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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BV6 is a small molecule, bivalent IAP antagonist that binds to the c-IAP1 and XIAP BIR2-BIR3 domains with Kd of 0.46 and 0.029 nM, respectively.
BV6 treatment results in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.
BV6 also induces induce TNFα-dependent cell death, exhibits single-agent cell killing activity in EVSA-T cell line (IC50=14 nM).
| M.Wt | 1205.573 | |
| Formula | C70H96N10O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 58 mg/mL |
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| Chemical Name/SMILES |
L-Phenylalaninamide, 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl- |
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1. Varfolomeev E, et al. Cell. 2007 Nov 16;131(4):669-81.
2. Vanlangenakker N, et al. Cell Death Differ. 2011 Apr;18(4):656-65.
3. Schirmer M, et al. Cell Death Dis. 2016 Jan 14;7:e2052.
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