Chemical Structure : BVL3572S
CAS No.:
1258544-63-6
BVL3572S
Catalog No.: PC-27995Not For Human Use, Lab Use Only.
BVL3572S is a potent bactericidal compound potently inhibits Mtb growth (MIC90=1.7 uM, Mtb H37Rv) and is bactericidal, inhibits two essential pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA, disrupting L-His and L-Ala biosynthesis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BVL3572S is a potent bactericidal compound potently inhibits Mtb growth (MIC90=1.7 uM, Mtb H37Rv) and is bactericidal, inhibits two essential pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA, disrupting L-His and L-Ala biosynthesis.
BVL3572S shows broad-spectrum activity against Gram-positive and Gram-negative bacteria.
BVL3572S inhibits Mtb growth by targeting histidine and alanine biosynthesis, has a broad impact on intrabacterial amino acid levels.
BVL3572S synergizes with the second-line antibiotic D-cycloserine.
Physicochemical Properties
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M.Wt
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257.09
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Formula
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C9H9BrN2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3S)-3-Amino-7-bromo-3,4-dihydro-1-hydroxy-2(1H)-quinolinone
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References
1. Zainab Edoo, et al. Cell Chem Biol. 2026 Aug 11:S2451-9456(26)00281-3.
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