BVT-14225 |CAS:376638-65-2 Probechem Biochemicals

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Chemical Structure : BVT-14225

CAS No.: 376638-65-2

BVT-14225 (BVT14225, BVT 14225)

Catalog No.: PC-45407Not For Human Use, Lab Use Only.

BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$178	In stock
25 mg	$298	In stock
50 mg	$458	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM.
BVT-14225 displays >200-fold selectivity over human and murine 11β-HSD2.
BVT-14225 reduces glucose levels in diabetic KKA(y) mice.

Physicochemical Properties

M.Wt	401.9313
Formula	C16H20ClN3O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 27 mg/mL
Chemical Name/SMILES	4-Thiazoleacetamide, 2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-

References

1. Barf T, et al. J Med Chem. 2002 Aug 29;45(18):3813-5.

2. Vicker N, et al. J Steroid Biochem Mol Biol. 2007 May;104(3-5):123-9.

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BVT-14225 (BVT14225, BVT 14225)

Biological Activity

Physicochemical Properties

References

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