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BW-031 iodide

Chemical Structure : BW-031 iodide

CAS No.: 2074714-47-7

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BW-031 iodide (BW031 iodide)

Catalog No.: PC-47030Not For Human Use, Lab Use Only.

BW-031 iodide is a potent cationic sodium channel inhibitor, inhibited Nav 1.7 (IC50=9.5 uM) and Nav 1.1 channels with approximately sixfold greater potency than QX-314.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BW-031 iodide is a potent cationic sodium channel inhibitor, inhibits Nav 1.7 (IC50=9.5 uM) and Nav 1.1 channels with approximately sixfold greater potency than QX-314.
    BW-031 inhibited inflammatory pain in guinea pig model of citric acid-induced cough.
    BW-031 produced more effective and longer-lasting inhibition of pain than QX-314 in the mouse UV burn model.

    Physicochemical Properties

    M.Wt 430.374
    Formula C19H31IN2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Piperidinium, 1-[1-[[(2,6-dimethylphenyl)amino]carbonyl]propyl]-1-ethyl-, iodide (1:1)

    References

    1. Ivan Tochitsky, et al. Br J Pharmacol. 2021 Oct;178(19):3905-3923.

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