Balicatib (AAE581)

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Chemical Structure : Balicatib

CAS No.: 354813-19-7

Catalog No.: PC-21937Not For Human Use, Lab Use Only.

Balicatib (AAE581) is a potent, selective and orally active and selective cathepsin K inhibitor with IC50 of 22 nM.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
50 mg	$298	In stock
100 mg		Get quote

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Biological Activity

Balicatib (AAE581) is a potent, selective and orally active and selective cathepsin K inhibitor with IC50 of 22 nM.
Balicatib (AAE581) displays 10-100-fold more potent in cell-based enzyme occupancy assays than cathepsin B, L, and S.
Balicatib (AAE581) stimulates periosteal bone formation in monkeys.

Physicochemical Properties

M.Wt	411.55
Formula	C23H33N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(4-propylpiperazin-1-yl)benzamide

References

1. Falgueyret JP, et al. J Med Chem. 2005 Dec 1;48(24):7535-43.

2. Jerome C, et al. Osteoporos Int. 2011 Dec;22(12):3001-11.

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