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Balinatunfib

Chemical Structure : Balinatunfib

CAS No.: 2248726-53-4

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Balinatunfib (SAR-441566, SAR441566)

Catalog No.: PC-24508Not For Human Use, Lab Use Only.

Balinatunfib (SAR441566) is a potent, oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, binds to human TNF with SPR Kd of 15.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Balinatunfib (SAR441566) is a potent, oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, binds to human TNF with SPR Kd of 15.1 nM.
SAR441566 potently inhibits zymosan-activated CD11b expression on granulocytes in human whole blood.
SAR441566 inhibited the expression of CD11b in zymosan-stimulated human whole blood with an IC50 of 35 nM.
SAR441566 occupied human TNF with an OCC50 for total compound (includes protein bound) of 14.3 nM.
Balinatunfib (SAR441566) stabilizes an asymmetrical form of the soluble TNF trimer, compromises downstream signaling and inhibits the functions of TNF in vitro and in vivo.

Physicochemical Properties

M.Wt 502.53
Formula C27H24F2N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1R,11R)-5-[2-(1-aminocyclobutyl)pyrimidin-5-yl]-18-(difluoromethoxy)-12-methyl-2,9,12-triazapentacyclo[9.8.1.02,10.03,8.014,19]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

References

1. Vugler A, et al. Front Pharmacol. 2022 Nov 16;13:1037983.

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