Balovaptan (RG7314, RO5285119) is a potent, selective vasopressin-1 receptor antagonist with Kb of 0.39 nM at the human V1a receptor.
Balovaptan (RG7314, RO5285119)displays outstanding functional selectivity against human V2 (3888-fold) and OT (2735-fold) receptors.
Balovaptan (RG7314, RO5285119) also shows no significant off-target activities except for the human 5HT2B receptor in a diverse 120-target selectivity screen.
