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Bamlanivimab

Chemical Structure : Bamlanivimab

CAS No.:

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Bamlanivimab (LY-CoV555, LY3819253, Ab169)

Catalog No.: PC-38875Not For Human Use, Lab Use Only.

Bamlanivimab (LY-CoV555) is a potent, recombinant, neutralizing human IgG1 monoclonal antibody (mAb) against the spike protein of SARS-CoV-2, binds to SARS-CoV-2 spike protein RBD and prevents its interaction with ACE2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Bamlanivimab (LY-CoV555) is a potent, recombinant, neutralizing human IgG1 monoclonal antibody (mAb) against the spike protein of SARS-CoV-2, binds to SARS-CoV-2 spike protein RBD and prevents its interaction with ACE2.
LY-CoV555 pretreatment reduces viral replication and load in the lower respiratory tract of rhesus macaques challenged with SARS-CoV-2.
LY-CoV555 displayed high protection potency, supporting its clinical development and testing as a therapeutic for the treatment and prevention of COVID-19.

Isotype: IgG1-kappa.
Anti-[human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein], human monoclonal antibody.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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