Chemical Structure : Bapotulimab
CAS No.:
Bapotulimab
(BAY1905254)
Catalog No.: PC-38854Not For Human Use, Lab Use Only.
Bapotulimab (BAY 1905254) is a human/mouse/monkey cross-reactive antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2), blocks the immunosuppressive activity of ILDR2 for cancer immunotherapy.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Bapotulimab (BAY 1905254) is a human/mouse/monkey cross-reactive antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2), blocks the immunosuppressive activity of ILDR2 for cancer immunotherapy.
Bapotulimab (BAY 1905254) promotes T-cell activation in vitro and enhances antigen-specific T-cell proliferation and cytotoxicity in vivo in mice.
Bapotulimab (BAY 1905254) also showed potent efficacy in various syngeneic mouse cancer models. Bapotulimab (BAY 1905254) demonstrated synergistic antitumor effects in combination with anti-PD-L1, an immunogenic cell death-inducing chemotherapeutic, or with tumor antigen immunization.
Isotype: IgG2-kappa
Anti-[human ILDR2 (immunoglobulin like domain containing receptor 2,
C1orf32)], human monoclonal antibody.
Physicochemical Properties
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M.Wt
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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