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Barecetamab

Chemical Structure : Barecetamab

CAS No.:

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Barecetamab (ISU104)

Catalog No.: PC-38855Not For Human Use, Lab Use Only.

Barecetamab (ISU 104) is a highly potent, fully human anti-ErbB3 monoclonal antibody, binds potently and specifically to the NRG1 binding region of domain 3 of ErbB3, exhibits potent antitumorigenic activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Barecetamab (ISU 104) is a highly potent, fully human anti-ErbB3 monoclonal antibody, binds potently and specifically to the NRG1 binding region of domain 3 of ErbB3, exhibits potent antitumorigenic activity.
Barecetamab (ISU 104) inhibited ligand binding, ligand-dependent heterodimerization and phosphorylation, and induced the internalization of ErbB3.
Barecetamab (ISU 104) inhibits downstream Akt phosphorylation and cell proliferation. Barecetamab (ISU 104) demonstrates anticancer efficacy in xenograft models of various cancers.
Isotype: IgG1-lambda
Anti-[human ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)], human monoclonal antibody.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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