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Chemical Structure : Batefenterol
CAS No.: 743461-65-6
Catalog No.: PC-43305Not For Human Use, Lab Use Only.
Batefenterol (GSK961081, TD-5959) is a bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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Batefenterol (GSK961081, TD-5959) is a bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.
Batefenterol shows weak effect on β1.
Batefenterol is the first MABA compound to enter clinical trials and demonstrate proof of concept and efficacy in COPD.
| M.Wt | 740.2438 | |
| Formula | C40H42ClN5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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| Chemical Name/SMILES |
Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester |
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1. Hughes AD, et al. J Med Chem. 2015 Mar 26;58(6):2609-22.
2. Ambery C, et al. Drugs R D. 2015 Sep;15(3):281-91.
3. Ambery C, et al. Clin Pharmacol Drug Dev. 2016 Sep;5(5):399-407.
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