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Chemical Structure : Batiraxcept
Catalog No.: PC-38856Not For Human Use, Lab Use Only.
Batiraxcept (AVB‐S6‐500, AVB-500) is a first-in-class Fc fusion protein of the extracellular domain of AXL that binds the GAS6 ligand thereby inhibiting AXL signaling.
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Batiraxcept (AVB‐S6‐500, AVB-500) is a first-in-class Fc fusion protein of the extracellular domain of AXL that binds the GAS6 ligand thereby inhibiting AXL signaling.
Batiraxcept (AVB‐S6‐500, AVB-500) neutralized growth arrest-specific 6 (GAS6) protein and effectively inhibited AXL signaling in preclinical cancer models.
ABatiraxcept (AVB‐S6‐500, AVB-500) binds GAS6 with low femtomolar range affinity to effectively bind GAS6 and eliminate its ability to stimulate the AXL pathway.
Human tyrosine-protein kinase receptor UFO (AXL oncogene) fragment (8-202, 1-195 in the current sequence), variant (G14>S7, A54>V47, D69>G62, V74>A67, G109>R102), fused via peptidyl linker (196GGGGS200) to a human immunoglobulin G1 Fc fragment (201-426, C-terminal Lys residue deleted), dimer, glycosylated, produced in Chinese hamster ovary (CHO) cells.
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| Appearance | Solid | |
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10 mM in DMSO |
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