Bax inhibitor peptide V5 (Val-Pro-Met-Leu-Lys, BIP-V5) is cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation.
Bax inhibitor peptide V5 inhibits Bax-mediated apoptosis in vitro; inhibit anti-cancer drug-induced apoptosis in vitro.
Bax inhibitor peptide V5 upregulats expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-kappaB-p65 by 10, 30, and nearly 50%, respectively, on pancreatic islets in a mouse model.
Physicochemical Properties
M.Wt
586.7875
Formula
C27H50N6O6S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 30 mg/mL
Chemical Name/SMILES
L-Lysine, L-valyl-L-prolyl-L-methionyl-L-leucyl-
References
1. Sawatzky DA, et al. Am J Pathol. 2006 Jan;168(1):33-41.
2. Rivas-Carrillo JD, et al. Diabetes. 2007 May;56(5):1259-67.
3. Yoshida T, et al. Biochem Biophys Res Commun. 2004 Sep 3;321(4):961-6.
