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Chemical Structure : Bax inhibitor peptide V5
CAS No.: 579492-81-2
Catalog No.: PC-47486Not For Human Use, Lab Use Only.
Bax inhibitor peptide V5 (Val-Pro-Met-Leu-Lys, BIP-V5) is cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Bax inhibitor peptide V5 (Val-Pro-Met-Leu-Lys, BIP-V5) is cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation.
Bax inhibitor peptide V5 inhibits Bax-mediated apoptosis in vitro; inhibit anti-cancer drug-induced apoptosis in vitro.
Bax inhibitor peptide V5 upregulats expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-kappaB-p65 by 10, 30, and nearly 50%, respectively, on pancreatic islets in a mouse model.
| M.Wt | 586.7875 | |
| Formula | C27H50N6O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
L-Lysine, L-valyl-L-prolyl-L-methionyl-L-leucyl- |
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1. Sawatzky DA, et al. Am J Pathol. 2006 Jan;168(1):33-41.
2. Rivas-Carrillo JD, et al. Diabetes. 2007 May;56(5):1259-67.
3. Yoshida T, et al. Biochem Biophys Res Commun. 2004 Sep 3;321(4):961-6.
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