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Bay K-8644

Chemical Structure : Bay K-8644

CAS No.: 71145-03-4

Bay K-8644 (Bay K8644)

Catalog No.: PC-62070Not For Human Use, Lab Use Only.

Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo.
Bay K-8644 enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts (MEFs) to induce pluripotent stem cells (iPSCs) combination with BIX-01294.

Physicochemical Properties

M.Wt 356.3
Formula C16H15F3N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

References

1. Wang W, et al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32.

2. Greenberg DA, et al. Brain Res. 1984 Jul 9;305(2):365-8.

3. Bourson A, et al. Eur J Pharmacol. 1989 Feb 7;160(3):339-47.

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