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BeKm-1

Chemical Structure : BeKm-1

CAS No.:

BeKm-1 (BeKm 1)

Catalog No.: PC-60837Not For Human Use, Lab Use Only.

BeKm-1 is a potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BeKm-1 is a potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels.
BeKm-1 displays no effect at 100 nM on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/KCNQ3, KCNQ4 channels, and minimal effect on rELK1.
BeKm-1 prolongs QTc intervals significantly and concentration-dependently (4.7 and 16.3% at 10 and 100 nM, respectively).

Physicochemical Properties

M.Wt 4091.65
Formula C174H261N51O52S6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

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