Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Beclabuvir
Catalog No.: PC-63571Not For Human Use, Lab Use Only.
Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively; inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of <30 nM; the combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1 in clinical trials.
HCV Infection
Phase 1 Discontinued
| M.Wt | 659.846 | |
| Formula | C36H45N5O5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Gentles RG, et al. J Med Chem. 2014 Mar 13;57(5):1855-79.
2. Sims KD, et al. Antimicrob Agents Chemother. 2014 Jun;58(6):3496-503.
3. Everson GT, et al. Gastroenterology. 2014 Feb;146(2):420-9.
4. Pelosi LA, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5230-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
