Chemical Structure : Beclabuvir hydrochloride
CAS No.:
958002-36-3
Beclabuvir hydrochloride
(BMS791325;BMS-791325)
Catalog No.: PC-63572Not For Human Use, Lab Use Only.
Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively; inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of <30 nM; the combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1 in clinical trials.
HCV Infection
Phase 1 Discontinued
Physicochemical Properties
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M.Wt
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696.304
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Formula
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C36H46ClN5O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo[3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide hydrochloride
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References
1. Gentles RG, et al. J Med Chem. 2014 Mar 13;57(5):1855-79.
2. Sims KD, et al. Antimicrob Agents Chemother. 2014 Jun;58(6):3496-503.
3. Everson GT, et al. Gastroenterology. 2014 Feb;146(2):420-9.
4. Pelosi LA, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5230-9.
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