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Chemical Structure : Befiradol
CAS No.: 208110-64-9
Catalog No.: PC-61625Not For Human Use, Lab Use Only.
Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.
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Befiradol (F13640, NLX-112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.
Befiradol (F13640, NLX 112) exhibits agonist efficacy greater than for (±)8-OH-DPAT or buspirone.
Befiradol (F13640, NLX 112) stimulates 'total G-proteins', but unlike (±)8-OH-DPAT and buspirone, more potent for Gαo activation, in rat hippocampal membranes.
Befiradol (F13640, NLX 112) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC in rats, activates both 5-HT(1A) autoreceptors and postsynaptic 5-HT(1A) receptors in prefrontal cortex with a similar potency.
| M.Wt | 393.857 | |
| Formula | C20H22ClF2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone |
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1. Bollinger S, et al. J Med Chem. 2010 Oct 14;53(19):7167-79.
2. Lladó-Pelfort L, et al. Psychopharmacology (Berl). 2012 May;221(2):261-72.
3. Newman-Tancredi A, et al. J Pharm Pharmacol. 2017 Sep;69(9):1178-1190.
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