Befiradol (F13640, NLX-112) | 5-HT1A agonist

Chemical Structure : Befiradol

CAS No.: 208110-64-9

Befiradol (F 13640, NLX-112)

Catalog No.: PC-61625Not For Human Use, Lab Use Only.

Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.

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5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$268	In stock
50 mg	$428	In stock
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Biological Activity

Befiradol (F13640, NLX-112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.
Befiradol (F13640, NLX 112) exhibits agonist efficacy greater than for (±)8-OH-DPAT or buspirone.
Befiradol (F13640, NLX 112) stimulates 'total G-proteins', but unlike (±)8-OH-DPAT and buspirone, more potent for Gαo activation, in rat hippocampal membranes.
Befiradol (F13640, NLX 112) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC in rats, activates both 5-HT(1A) autoreceptors and postsynaptic 5-HT(1A) receptors in prefrontal cortex with a similar potency.

Physicochemical Properties

M.Wt	393.857
Formula	C20H22ClF2N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone

References

1. Bollinger S, et al. J Med Chem. 2010 Oct 14;53(19):7167-79.

2. Lladó-Pelfort L, et al. Psychopharmacology (Berl). 2012 May;221(2):261-72.

3. Newman-Tancredi A, et al. J Pharm Pharmacol. 2017 Sep;69(9):1178-1190.